孢子指定

National Cancer Institute designates UCLA brain cancer program a site of research excellence

$11.400万年 grant will help to advance work in prevention, detection and treatment

09/19/2017

脑癌项目 皇冠hga025大学洛杉矶分校健康约翰逊综合癌症中心 和  皇冠hga025大学洛杉矶分校脑肿瘤中心 has been designated a Specialized Program of 研究 Excellence, 或孢子, 美国国家癌症研究所, making it one of only five brain cancer programs nationwide to receive this national recognition and substantial research funding.

这款产品售价11美元.400万年, five-year grant that recognizes UCLA's brain cancer program as one of the best in the country. 该项目支持预防研究, detection and treatment of one of the most lethal and deadly cancers, which often receives far less funding than other types of cancers.

The SPORE designation is the second for the 皇冠hga025大学洛杉矶分校健康约翰逊综合癌症中心. 2002年10月 前列腺癌项目 被命名为卓越研究中心, and was renewed in August 2013 for its third five-year funding cycle, 收到11美元.国家癌症研究所拨款六百万.

These grants promote cooperation among scientists in different disciplines, and UCLA's program will partner researchers and clinicians to translate basic research from the laboratories into patient clinical trials much more quickly and effectively, 说 Dr. Linda Liau, professor and chair of neurosurgery at the David Geffen 医学院 at UCLA and director of the UCLA 脑瘤 Program.

“We now stand at the beginning of a paradigm shift in how we underst和 biology of brain cancer, 并且可以开发更有效的预防方法, diagnosis and treatment based on our new scientific understanding of why previous treatments have failed,刘说. “The brain cancer SPORE gives us critical initial support and resources to foster collaboration and accelerate new research and discoveries.”

Dr. 迈克尔Teitell, 皇冠hga025大学洛杉矶分校健康约翰逊综合癌症中心主任, 说 the grant is “a superb example of excellence in interdisciplinary research at UCLA, and it will allow us to have a major impact on the way we attack brain cancer. 我们现在可以采取多方面的方法来对付这种疾病, 在更容易治疗的时候及早发现, 确定特定的免疫和基因疗法, and bring these observations in the lab quickly to the clinic so we can help those who are fighting this disease every day.”

美国癌症协会估计有23,800 malignant primary tumors of the brain or spinal cord will be diagnosed this year, 和16,预计今年将有700人死于这种疾病.

UCLA's program will work to unravel the genetic mysteries of brain cancer and develop new and better ways to detect and treat it. 四个初步重点项目将构成该计划的核心:

• Drs. Linda Liau and Robert Prins will investigate the mechanisms that make it possible for brain tumors to evade and overcome immunotherapy. 研究人员希望通过了解这些因素, they can dramatically enhance the benefit of cancer vaccines that are already being tested in people by combining them with the appropriate immune checkpoint 抑制剂.
• Drs. 盖Cloughesy, Steven Bensinger and David Nathanson will focus on how metabolism can affect and regulate tumor resistance to targeted therapies. These insights can allow scientists to potentially exploit metabolic vulnerabilities, 比如代谢应激, to induce the death of cancer cells and improve how patients respond to targeted 抑制剂 by combining them with drugs that induce cell death.
• Drs. Frank Pajonk and Leia Nghiemphu will investigate new strategies to block the process by which radiation therapy can cause non-cancerous cells to become cancerous. People who are treated with traditional radiation often suffer a recurrence of their cancer, and this research could help improve clinical outcomes for people with brain and other cancers by combining radiation therapy with drugs that prevent the conversion of non-cancerous cells to cancerous ones.
• Drs. Albert Lai and Harley Kornblum will study how glioblastoma can become resistant to isocitrate dehydrogenase, 或IDH, 抑制剂, which are a promising new type of drug that targets a specific mutation in brain cancer cells. The scientists hope that by understanding the epigenetics of this process, it could lead to the development of new treatments for people with glioblastomas that harb或IDH mutations by combining IDH 抑制剂 with epigenetic drugs.

“The SPORE designation will build upon our already successful and nationally recognized brain cancer program,刘说. “We are tremendously grateful for the support from the [National Cancer Institute] SPORE program, 皇冠hga025大学洛杉矶分校健康约翰逊综合癌症中心 和 UCLA David Geffen 医学院. 在一起, we look forward to making vital advances in developing new therapies for brain cancer and improving the lives of people with this disease 和ir families.”

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